Professor Paul Bloom: The final topic of the course is clinical psychology, also known as abnormal psychology or psychopathology, and this, for many of us, is what psychology is really about. It's about mental illness. It's about clinical psychologists. And we started talking about this when Dr. Nolen-Hoeksema gave her guest lecture last week and I want to continue through this today. It is a topic of tremendous scientific importance but also a topic of great personal importance for many of us. Many of the people in this room have been mentally ill, strictly speaking, at some point in their lives. Some of you are under some sort of therapy or treatment or medical intervention right now. Some of you are on Prozac or Zoloft or Ambien or Wellbutrin or any of those other medications to deal with psychological problems you are facing. Others are also talking to psychiatrists, psychologists, social workers, and other people.心理学空间@3vs`8\ kmj B3e/i
Many of you who are not at this point mentally ill will become mentally ill during your stay at Yale. [laughter] And this is a difficult period in many people's lives and it's a period of people's lives where mental illness emerges in many of us. By one estimate, one half of all college graduates in the United States – and the number is very high with college graduates, highly educated people – one half of you will have some sort of mental illness in your life serious enough to require some sort of treatment. Those of you not directly affected with mental illness yourselves will no doubt experience your loved ones, your family, your friends getting some sort of illness, be it Alzheimer's or schizophrenia or depression or some sort of anxiety disorder. So the personal importance of clinical psychology, the personal importance of understanding what can go wrong and how best to treat it, simply can't be underestimated.心理学空间{j ~|2OB%nOs
Q,s [T+U"j;c0Now, when we talk about mental disorders, the scope of this is very broad. It includes the prototypical schizophrenic which you could see on the streets of New Haven, somebody walking and gesturing and talking to themselves and sometimes screaming. It includes alcohol addiction and cocaine addiction and other addictions. It includes somebody with Down syndrome or autism, an old person losing his memory, a teenager falling into a deep depression, somebody with a severe social phobia to the extent that he or she can't leave the house. Then there are also very hard cases where it's difficult to say one way or another--that guy's photographing me as I'm talking and it's freaking me out [laughs] [laughter] in kind of a social phobia way. There's difficult cases where it's just hard to tell mental illness from just [laughter as Professor Bloom waves goodbye to the photographer] bad behavior in general. So, consider a killer without a conscience or a mobster like John Gotti. Is he mentally ill? And this is a question which is a deep one and we'll wrestle with it a little bit actually towards the end of this lecture.心理学空间;[LyWz/rY
What about somebody who acts in a kind of unusual or zany way? This is originally supposed to be a picture of the character Kramer on "Seinfeld" but, given his unusual antics in the last few months, it could be a picture of the actor who plays him who got into all sorts of trouble. What about someone who is just kind of wacky? At what point does wackiness move into the domain of mental illness? What about unusual lifestyles such as extreme altruism? Batman devotes most of his life to helping others. He sleeps one hour a night and this hour is fraught with nightmares and then he fights crime. What about somebody, and this was a case reported inThe New Yorkera few months ago, who has lots of money and a loving family and has his kidney removed to help a stranger? And he says, "I have two kidneys. It's minor pain, a minor operation. I could save someone's life." And his wife says, "You're mentally ill. That's just crazy to do that." Where do we draw the line? And so, there are these great philosophical and moral questions over the boundaries and how to think about mental illness.心理学空间T?%z$K:V
So, how should we think about mental illness? Well, there are some answers we could quickly dispense with. It used to be thought that severe mental illness was a result of demonic possession. If you read the Gospels, Jesus Christ wandered around a lot, met crazy people and exorcised the demons from their bodies. It was a common way of thinking about craziness. We now believe that this is not true. What about--yeah, it's not true. What about social deviants? Some people including the psychiatrist Thomas Szasz claim that when we label somebody as mentally ill this is not a medical decision. It's rather a social decision designed to ostracize people who deviate from society's norms, to ostracize them and rid them of moral agency. It's not that we disagree with them. It's not even that we see them as evil. Rather, we see them as sick and as such we don't even have to accord to them the respect that we accord to criminals.
Now, this is not entirely an unreasonable view. In many countries around the world, dissidents, people who argue against the state, are often determined to be mentally ill and thrown in asylums. Blacks in the United States who tried to escape from slavery were described as having a mental illness. Why would they want to do so unless they were mentally ill? Up until 1973, to be a homosexual, to be gay, would count in the official records of how we classify illness as being mentally ill. And many people saw this, and we see this now, not so much as reflecting a sort of unbiased medical analysis but rather as reflecting biases that people have against gay people. And these are political and social and moral biases. They are not objective medical judgments. Even now I've been recording every president that has been the president of the United States in my memory including Bush and particularly Clinton has been described by his opponents not merely as awful, evil, terrible, "hate his policies," but as mentally ill. Every president at some point or another, some bright, intelligent person figures to call him a psychopath and put that inTimemagazine. Now, put aside whether--the extent to which these things are accurate, point being that we often use medical labels, particularly labels like "psychopath," "schizophrenic," "delusional," to ostracize and pick out people we disagree with.
"m2k,tv Z"fW0At the same time though, this is not entirely right. People go too far when they say there's no such thing as mental illness. Some people are mentally ill in a very real sense of "illness," in the same sense we would describe somebody as physically ill if they were to have cancer. This illness damages their functioning. They cannot function well. They do not tend to be more creative or more productive or more vivacious. Rather, for – with very few exceptions; possibly some exceptions revolving around mania as Dr. Nolen-Hoeksema discussed – with very few exceptions being mentally ill is just very bad for you in every possible way. Moreover, when people are treated, when people get better, they become more competent, happier, better able to participate in the world, and they do not choose to go back to their mental illness, suggesting that it really is illness in the serious sense. And so the modern treatment of psychological disorders treats them as disorders like medical disorders. Schizophrenia is as much a disease as is cancer and should be thought of in the same way.心理学空间6g4x CGtfh
-~Ew$m3dqs0There's a whole field of abnormal psychology of tremendous scope. We've already discussed many mental illnesses in the context of other things. So, for instance, we talked about amnesia in the context of memory and how it works. We talked about autism in the context of social reasoning. There are many more and I'm not going to read through them. These are the major categories just for people's interest fromThe Diagnostic and Standard Manual.You don't have to--you're not responsible for all of these. And this is an illustration, which people might find interesting, of sex differences in these--in the major disorders. And the patterns, as you could see, are kind of neat. Women are more prone to have anxiety disorders and mood disorders. Men are much more likely to suffer from substance disorders, particularly alcoholism. Schizophrenia is sort of evenly matched but antisocial personality disorders, sometimes known as sociopathy or psychopathy, is predominantly male. And we'll turn to that a bit later.心理学空间(_(Z5z:q8N\ ^9]9OI/|
4TS0zw.N)Pq`0Here are the major ones which I want to review today. I'm not going to talk about mood disorders at all because this was the topic of the superb lecture we heard last week but I want to quickly review schizophrenia, the class of disorders known as anxiety disorders, the class of disorders known as dissociative disorders, and the class of disorders known as personality disorders. And these are the main psychological problems. When a psychologist or psychiatrist does his or her work, they're predominantly focused on somebody who has one of these problems. Some of them are rare but some of them such as anxiety disorders and the mood disorders are very common.心理学空间Z[x*wiE ^
k0CsDh'F!t/h;T0About 1% of the world's population suffers from schizophrenia and this is the most common reason for being in a mental hospital. And the reason for that is because of its severity, because of how terrible an illness it is. Schizophrenics have been described as the lepers of the twentieth century by people who pointed out that in the last hundred years people who are schizophrenics are just--there's no place for them in society. They're shunned. They're rejected. We have no idea how to treat them or how to help them. The roots of schizophrenia come from the terms "split" and "mind" but the idea is there is a split from reality. It's important to stress the sort of etymological point because sometimes people confuse schizophrenia with something--with split personality and they somehow think schizophrenia refers to having multiple personalities. This is incorrect. A multiple personality disorder is an entirely different disorder. It's a sort of dissociative disorder. Split personality--people with schizophrenia do not have multiple personalities. What they have is a problem with relating to reality. It's roughly equally split between the genders but it strikes men earlier and it happens between--around these ages and as you could see roughly--and, as you could see, it is the sort of thing that could make its first occurrence while you're in college or university.
;Y+Cf.gWG$C|oX0There are five symptoms – main symptoms of schizophrenia. Four of them are the positive symptoms, meaning things that you do, that you have that's unusual. One is a negative symptom, something that you don't have, something that a schizophrenic lacks. So, just to walk through them, a hallucination is an experience, a sensory experience, that isn't real. So, the most typical hallucinations are auditory. Schizophrenics hear voices. They hear sounds, particularly people telling them to do things, that aren't real. Sometimes there are auditory--there are visual hallucinations or hallucinations of smell and taste but a typical hallucination is auditory. Sometimes the voices are seen from coming from oneself and so you could sometimes stop the hallucinations by doing things like humming or counting or holding your mouth open. And some schizophrenics will do this in an attempt to block auditory hallucinations.
There are delusions. The difference between a hallucination and a delusion is a hallucination is a sensory experience that's wrong, that just didn't really happen. A delusion is a belief that isn't right. It's a belief that you shouldn't be having. Now, again, the question of what counts as a delusion and what counts as accuracy can be a controversial one. Richard Dawkins titled his recent bookThe God Delusion,describing this mass delusion that many people have that they believe there's a supernatural being who created the universe and who is watching them. Some people find that offensive, to call it a delusion and people will have different views.心理学空间 I$t]@Dm V6urd}
G3?p6Fr#H(QpP0The delusions schizophrenics have tend to be pretty clearly weird and wrong. They often tend to believe they are famous people. Many schizophrenics have a religious bent and believe that they are Jesus Christ. In 1959, there was a Michigan hospital that had three Jesus Christs in it and they would meet and talk. One theme of delusions is what's called "ideas of reference." And ideas of reference are you think that there's all sorts of things happening that revolve around you. You hear people whispering and you think they're talking about you. You pick up the newspaper and you believe that there's coded messages in it that are directed towards you. You might believe that there is some sort of omnipotent, powerful force conspiring against you or trying to manipulate you like aliens or the FBI, the CIA, the government. You might believe that they have some sort of evil plan in mind for you.
-_ oG m\4G0There is disorganized speech. Some schizophrenics babble. They talk and it's nonsense. If you listen to a schizophrenic on the street, sometimes what they're saying makes no sense at all, not merely that they're conveying ideas that are unreasonable but it's just garbled, it's just a mess. And sometimes there is disorganized behavior too, odd motor movements. And the most extreme cases of this are motor movements described as "catatonic" where the person doesn't move, often freezes in a position.心理学空间(]/@7D,PP6M}
,H9EN$s/s3P4g0Those are all positive symptoms. A major negative symptom in schizophrenia is absence of normal thought or affect, affect meaning emotion. So some schizophrenics might just not talk. They might have very low emotional responses. They might not care about anything.心理学空间]&m_2_T,Z
;V:M Jd}{3tU$e0The basic psychological misfunction--oh, sorry. There are different subtypes of schizophrenia. There are five major subtypes but I'm going to focus on the three major ones, the three most interesting ones. The first one is paranoid schizophrenia. So, paranoid schizophrenics believe that others are spying and plotting against them. And they often have delusions of grandeur. They often believe that other people are jealous of them. They might believe they have supernatural powers. They might believe that they're God or a messiah. The catatonic schizophrenics are unresponsive to their surroundings and often they'll just repeat what people say to them, they won't generate their own speech. And finally, the disorganized schizophrenics are maybe what you most think of when you think of somebody who is insane. They make no sense. They have delusions and hallucinations. They babble. They--their actions--they could be dangerous. They could be perceived as dangerous. They're unable to help themselves. They're unable to do anything in their lives.心理学空间U']-ak7Q8Z5B8H
z5A!g/\(r0It's hard to pin down exactly what's at root of all of these problems but a very general summary is that there is a problem – an inability to put together your thoughts and perceptions, to sequence them and coordinate them, to impose a logical structure and a reasonable, realistic temporal sequence on your experience. This is the core thing going wrong but what happens as a result of this is you lose contact with others, you lose social contact. Losing social contact means you don't get much reality checking. If I start acting weird and nobody cares, I could just get weirder and weirder, while if I'm in a good social group of people who care about me often the situation could be brought under control. So, schizophrenia is sort of a vicious circle where you have this cognitive problem. Then you have problems losing contact with others, exaggerating the cognitive problem, and so on.心理学空间)\1Qwza/o^ T;u
A lot of people have studied the genetics of schizophrenia. It's clear enough that there is a powerful genetic component. I could--you can tell how much at risk somebody is for becoming schizophrenic based on the schizophrenia and illness of their family members. In particular, if you have an identical twin who's schizophrenic, your odds are about a half of becoming schizophrenic yourself. At the same time, and we dealt with this as well when we talked about issues of sexual orientation, the fact that identical twins the odds are only 50% means there has to be an environmental component to it. If it was entirely genetic, it would be 100%. And so one claim--one way of looking at it is your genes make you vulnerable to schizophrenia but whether or not you become schizophrenic depends on what happens in your environment. You're sensitive to certain triggers.心理学空间L.c2vQ"Cc5U+g({
Some triggers might happen early. There is some evidence that schizophrenia is associated with trauma even at the point of birth. And there's some other evidence that schizophrenia is linked to viral infections. As an example, there are more schizophrenics born in the winter, subtle--a subtle difference but there seems to be a reliable effect of more schizophrenics born in the winter. More people get sick in the winter. At times when there's been some sort of epidemic or some sort of plague, this seems to cause a jump in the frequency of schizophrenics born at that time.
There's some recent research that ties schizophrenia to the possibility of toxoplasmosis, which is a disorder carried by cat feces. The experiment basically involved asking the parents of schizophrenics one question: "Did you own a cat when your child was born?" And if the answer was "yes," it seemed to correspond to a bit higher odds for schizophrenic families than for non-schizophrenic families.
2vC])y)n[ K0A different sort of trigger is stressful family environments. Schizophrenics seem to really have more stressful family environments than non-schizophrenics. Now, we have to be careful about this. We have to bring--we have to return to the sort of methodological cautions we had in mind when we talked about individual difference research in general. Remember we talked about the worst study in the world and one of the features of this was it was failing to pull apart cause and effect. It might be that having a difficult family environment ups your odds of becoming schizophrenic. On the other hand, it might also be that schizophrenic children or children who will become schizophrenic are difficult to deal with in certain ways causing a family environment. So, it's not clear whether the effect is from difficult family environment to later schizophrenia or from schizophrenia to difficult family environment.
There used to be a very popular theory of schizophrenia, which is that it was caused by excess dopamine. Dopamine, you'll remember, is a neurotransmitter. And there is some reason to take this seriously. Drugs that reduce dopamine provide some help in reducing symptoms. And if I give you a drug that shoots up your dopamine that will turn you into a temporary schizophrenic. You get what's called "amphetamine psychosis" and it'd give you--it can give you schizophrenic-like symptoms, hallucinations, delusions, that sort of thing. This--There might be something to this theory but we know now it can't be complete for at least two reasons. First, it doesn't explain the negative symptoms. It explains hallucinations and delusions and so on but it doesn't explain the loss of affect, the quietness, the stillness. Also, there seemed to be some sort of structural brain differences involving enlarged cerebral ventricles, involving reduced frontal lobe activity, suggesting that the problem with schizophrenia is a lot more complicated than others might have it, than the dopamine theory would have it.心理学空间U)SO1B1L
LLW)HsR E0I'll end with a mystery. And this mystery is discussed nicely in the Gray textbook. The symptoms of schizophrenia, the prevalence of schizophrenics, is similar wherever you go but less industrialized countries have a better rate of recovery from schizophrenia than industrialized countries. And nobody really knows why. I listed here three possibilities. One is that the families that were--that--in a less industrialized country there's more latitude and so there's less critical- less criticism. There's less use of antipsychotic medication. Antipsychotic medications help with the symptoms but they might also impair recovery. And finally, if you think of schizophrenia as a transient disorder, maybe that will in some sense, in some way, make that more likely to actually happen.